members.andrew reid  

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Research interests

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Current position :

Birthplace:

Alma mater:

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Ph.D. student

Gander, Newfoundland, Canada

Memorial University of Newfoundland (B.Sc., M.Sc.)

Behavioural Neuroscience

research interests top
 

Human brain lesion analysis using a primate connectivity database.

My main PhD project will be to apply the Macaque monkey brain connectivity data collated in the CoCoMac database to three-dimensional human brain lesion data obtained through structural and functional magnetic resonance imaging (MRI), in order to predict the functional effects of these lesions. The aim of this project is to demonstrate the possibility of using a computer database compiling a large number of anatomical research findings, to successfully predict the high-level functioning of neural tissue, and in particular the effects of specific tissue lesions upon this functioning. Generally speaking, such a predictive model may prove to be a useful and effective tool clinically, in that it can be used to guide diagnostic evaluation of a specific brain lesion. It might also prove valuable as a research tool, enabling the generation of specific testable hypotheses about the functioning of particular brain structures or networks.

 

Modelling and visualization of neuroscientific data.

A further interest of mine is to develop an open-source, extensible, Java-based environment to both model and visualize brain structure and function. This environment will include database functionality, including connections to CoCoMac and other publicly available neuroscientific datasets. The development of this tool is intended to provide a number of capabilities, including flexible static and dynamic modelling at various scales, and visualization of structures, connectivity, and model output. An online interface allowing visualization of various types of neuroscientific data, registered to a template model, is also in development.

New: the planned release date for the beta version of what I am tentatively calling the modelGUI project is 30 June, 2010. A pre-release version is now available; see the new Wiki site for details.


Click for larger screenshot

Relating cortical thinning and white matter degeneration.

Using a large dataset of imaging data obtained from elderly subjects with various degrees of white matter degeneration, we intend to investigate the relationship of such degeneration to cortical thinning patterns revealed through advanced imaging techniques developed at the McConnell Brain Imaging Center at McGill University. Using such comparisons may provide important insights into the functional organization of the brain, as well as better defining the patterns of age-related neurodegeneration.

curriculum vitae top
   
Research Career
 
1998 - 2003
Studied Psychology (Behavioural Neuroscience) at Memorial University of Newfoundland, St. John's, Newfoundland, Canada
2003
Awarded B.Sc. (hons) in Psychology (Behavioural Neuroscience) from Memorial University. Honours project involved behavioural and immunohistochemical data collection in a rat olfactory learning paradigm (McLean et al.)
2003 - 2006 Studied Experimental Psychology (Behavioural Neuroscience) at Memorial University
2007
Awarded M.Sc. in Experimental Psychology (Behavioural Neuroscience) from Memorial University. Masters thesis involved in vivo electrophysiological data collection in a rat dentate gyrus LTP paradigm (Harley et al.)
 
Teaching and Supervision
 
2006
Teaching Assistant, Memorial University. Involved supervising, advising, and grading ~100 second-year Psychology students, in the seminal semester of a new course entitled "Mind and Brain".
2007 - present
Laboratory Assistant, University Medical Center, Radboud University, Nijmegen, Netherlands. Involved supervising and assisting first-year medical students with various laboratory sessions.
 
Memberships
 
2005, 2009 Society for Neuroscience
2007-present Organization for Human Brain Mapping
 
Awards
 
2007 Canadian Psychological Association Certificate of Academic Excellence - Masters Thesis
2009
Organization for Human Brain Mapping Editor's Choice Award (for Reid et al., 2009: Optimization of cortical hierarchies)
 
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Peer-reviewed Articles
 
Bojak I, Oostendorp TF, Reid AT, Kötter R (2010). Connecting Mean Field Models of Neural Activity to EEG and fMRI Data. Brain Topography (in press).
Reid AT, van Norden AGW, de Laat KF, van Oudheusden LJB, Zwiers MP, Evans AC, de Leeuw FE, Kötter R (2009). Patterns of cortical degeneration in an elderly cohort with cerebral small vessel disease. Human Brain Mapping (in press). [pre-print version | link]
Reid AT, Harley CW (2009). An associativity requirement for locus coeruleus-induced long-term potentiation in the dentate gyrus of the urethane-anesthetized rat. Experimental Brain Research. [link]
Reid AT, Krumnack A, Wanke E, Kötter R (2009). Optimization of cortical hierarchies with continuous ranges and scales. Neuroimage. 47(2): 611-7. [pre-print version | link]
Bojak I, Oostendorp TF, Reid AT, Kötter R (2009). Realistic mean field forward predictions for the integration of co-registered EEG/fMRI. BMC Neurosci. 10: L2.
Bezgin G, Reid AT, Schubert D, Kötter R (2008). Matching spatial with ontological brain entities using integrated Java tools for visualization and database access. Neuroinformatics. 7(1): 7-22. [link]
Kötter R, Reid AT, Krumnack A, Wanke E, Sporns O (2007). Shapley ratings in brain networks. Frontiers in Neuroinformatics. 1: 2. [link]
 
Theses
 
2003
BSc. (Hons) Thesis: NMDA phosphorylation in olfactory preference learning: a critical step in neuronal plasticity?
2006
MSc. Thesis: An associativity requirement for noradrenergic dentate gyrus long-term potentiation in the urethane-anesthetized rat
 
Presentations
 
November
2005
Society for Neuroscience Annual Meeting, Washington, D.C. Poster presentation: Unpaired perforant path and locus coeruleus activations only transiently potentiate the evoked dentate gyrus population spike.
June
2008
Organization for Human Brain Mapping Annual Meeting, Melbourne, AU. Poster presentation: Age-related thinning of cortical grey matter.
October
2009
Helmholtz Alliance on Systems Biology Meeting, Heidelberg, DE. Short talk: Optimization of cortical hierarchies with continuous scales and ranges.