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Postdoctoral Researcher

Marbach a.N. (Germany)

Technical Biology, University of Stuttgart (Germany), PhD, Molecular Neurobiology, University of Groningen (Netherlands)

neuronal plasticity, barrel cortex, sensory deprivation, BDNF splice variants, primary cortical neurons, neurodegeneration, Alzheimer’s disease
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Synaptic plasticity is widely accepted to be the cellular basis of learning and memory processes. A crucial molecule for promoting neuronal plasticity is the brain-derived neurotrophic factor (BDNF). Neuron derived BDNF is subjected to complex transcriptional regulation through alternative splicing (transcripts BDNF I to IX), and post-transcriptional sorting and processing. The focus of my current research is to elucidate the functional role of alternatively spliced brain-derived neurotrophic factor (BDNF) variants on the molecular mechanisms underlying neuronal plasticity. Furthermore, I am interested molecular mechanisms of neurodegeneration (in particular Alzheimer’s disease) and strategies to combat brain damage by various molecular, pharmaceutical and immunological approaches.

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Research Career
 
1999-2005
Technical Biology, University of Stuttgart (Germany).
2005-2009
PhD, Molecular Neurobiology, University of Groningen (Netherlands).
 
 
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Peer-reviewed Articles
 
Ivica Granic, Marcelo F. Masman, Paul G.M. Luiten, Ulrich L.M. Eisel “Braak Staging” in Mouse Models for Alzheimer’s Disease. Am J Pathol 2010 (Accepted)
Ivica Granic, Csaba Nyakas, Paul G.M. Luiten, Ulrich L.M. Eisel, Laszlo G. Halmy, Gerhard Gross, Hans Schoemaker, Achim Möller, Volker Nimmrich. Calpain inhibition prevents amyloid-beta-induced neurodegeneration and associated behavioral dysfunction in rats. Neuropharmacology 2010 Jul 23. [Epub ahead of print].
Csaba Nyakas, Ivica Granic, Laszlo G. Halmy Pradeep Banerjee Paul G.M. Luiten. The Basal Forebrain Cholinergic System in Ageing and Dementia. Rescuing Cholinergic Neurons from Neurotoxic Amyloid-ß42 with Memantine. Behav Brain Res. 2010 May 27. [Epub ahead of print].
Ivica Granic, Marcelo F. Masman, Cornelius Mulder, Ingrid M. Nijholt, Pieter J.W. Naude, Ammerins de Haan, Emoke Borbely, Botond Penke, Paul G.M Luiten, Ulrich L.M. Eisel. LPYFDa neutralizes amyloid-beta-induced memory impairment and toxicity. Journal of Alzheimer’s Disease 2010 Jan;19(3):991-1005.
Jonathan Vinet, Eiko K. De Jong, H.W.G.M Boddeke, Vesna Stanulovic, Niske Brouwer, Ivica Granic, Ulrich L.M. Eisel , R.S.B. Liem, Knut Biber. Expression of CXCL10 in cultured cortical neurons. Journal of Neurochemistry 2010 Feb;112(3): 703-714.
Ivica Granic, Amalia M. Dolga, Ingrid M. Nijholt, Gertjan van Dijk, Ulrich L. M. Eisel. Inflammation and NF-?B in Alzheimer’s disease and Diabetes. Journal of Alzheimer’s Disease 2009 Apr;16(4):809-21.
Amalia M. Dolga, Ivica Granic, Ingrid M. Nijholt, Csaba Nyakas, Eddy van der Zee, Paul G. M. Luiten, Ulrich L. M. Eisel. Pretreatment with Lovastatin prevents N-Methyl-D-Aspartate-induced neurodegeneration in the Magnocellular Nucleus Basalis and behavioral dysfunction. Journal of Alzheimer’s Disease 2009 Jun;17(2):327-36.
Amalia M. Dolga, Ivica Granic, Thomas Blank, Hans-Guenther Knaus, Joachim Spiess, Paul G. M. Luiten, Ulrich L. M. Eisel, Ingrid M. Nijholt. TNFa-mediates neuroprotection against glutamate-induced excitotoxicity via NF-?B-dependent up-regulation of KCa2.2 channels. Journal of Neurochemistry 2008 107(4): 1158-1167.
Volker Nimmrich, Robert Szabo, Csaba Nyakas, Ivica Granic, Klaus G.Reymann, Ulrich H. Schroder, Gerhard Gross, Hans Schoemaker, Karsten Wicke, Achim Moller, Paul Luiten. Inhibition of Calpain Prevents N-Methyl-D-aspartate-Induced Degeneration of the Nucleus Basalis and Associated Behavioral Dysfunction. J Pharmacol Exp Ther 2008 327: 343-352.