H.H.L.M. Goossens, PhD
Donders Institute for Brain, Cognition and Behaviour
Department of Cognitive Neuroscience, Section Biophysics
Radboud University Nijmegen Medical Centre
Office 02.280 - Trigon building
NL 6525 EN Nijmegen
+31 24 36 10906
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In our Visuomotor Lab we investigate how the primate brain transforms sensory information into conscious percepts and voluntary motor acts. Our studies involve experiments with human subjects and with macaque monkeys that are trained to perform visuomotor tasks against positive rewards. Human participants are tested with the use of psychophysical and neuroimaging techniques. In macaques we also use neurophysiological techniques such as single-unit recordings, electrical microstimulation and local inactivation, that cannot be applied in human. Our goal is to understand exactly how the brain works. We are firmly convinced that only with this knowledge we can truly help patients suffering from the many disorders of perception, awareness and movement caused by debilitating brain diseases. Current projects focus on executive control mechanisms for action and perception in the frontoparietal cortex, optic-flow processing in extra-striate visual cortex, and on the neural underpinnings of saccadic search behaviour in exploring visual scenes.
<![if !supportLists]>· <![endif]>Read the Basel Declaration of Nov. 2010, signed by European scientists on how to conduct and communicate responsible animal research.
<![if !supportLists]>· <![endif]>Read about Brain Research Success Stories. They are designed to inform the public and elected officials about the recent successes and future potential of neuroscience.
<![if !supportLists]>· <![endif]>The need for non-human primates in neuroscience research. A short overview can be found in the brochure Primates in Medical Research. For more details, read the Weatherall report (UK) and the SCHER report (EU).
<![if !supportLists]>· <![endif]>Are you also tired of the false and misleading information spread by animal activists? This site shows how experiments with non-human primates are really carried out in Neuroscience labs around the world (from the Tübingen Max Plank Institute for Brain Research, Germany).
<![if !supportLists]>· <![endif]>An example of monkey neuroscience research: Neuro-prosthetics in the Pittsburgh Motor Lab (on Multimedia, click on their videos!)
<![if !supportLists]>· <![endif]>Standing up for science. See why Pro-Test, Americans for Medical Progress (AMP) and Speaking of Research think animal experiments are necessary in biomedical research. These public organizations aim to dispel the irrational myths promoted by anti-vivisectionists and to encourage people to stand up for science and human progress.
<![if !supportLists]>· <![endif]>Animal Research.Info provides reliable information from scientists worldwide about the contribution of animal research to medical advances. Look at this article to see why there is a need for non-human primates in cognitive neuroscience.
<![if !supportLists]>· <![endif]>How do researchers work with primates? Which species do they use? What has research with primates revealed? How are the primates looked after? These are the questions answered in the new iBook, Primates in Medical Research. A PDF version can be downloaded here.
In Nederland worden per jaar ca 600 duizend proefdieren gebruikt. Met andere woorden, er wordt per jaar één proefdier (typisch een muis of rat) gebruikt om ruim 25 Nederlanders uiteindelijk betere medische zorg te bieden. Het belang van fundamenteel onderzoek kan daarbij eigenlijk niet worden overschat. Wil je meer feitelijke achtergrondinformatie over dierproeven? Kijk dan op de website van de Stichting Informatie Dierproeven.
Hersenscans een alternatief voor proeven op apen? Helaas is dat een fabeltje. Lees bijvoorbeeld hier waarom.
<![if !supportLists]>· <![endif]>1987- 1993: Student at the University of Utrecht, NL. Degrees in Medical Biology and Biophysics. Research projects on human arm-muscle coordination and electrophysiology of sound localization in fish. Graduated with honor.
<![if !supportLists]>· <![endif]>1993-1997: Ph.D. student at the Department of Medical Physics and Biophysics, University of Nijmegen, NL. Research involved a series of electrophysiological (monkey Superior Colliculus) and behavioral (monkey and human) studies on saccade generation, eye-head movements and sound localization. Ph.D. thesis: 'Sensorimotor transformations and feedback signals involved in gaze control'. Cum laude promotion.
<![if !supportLists]>· <![endif]>1998-2000: Postdoctoral student at the Department of Physiology, University of Rotterdam, NL. Research on the role of cerebellar Long-Term Depression (LTD) in visual and vestibular stabilization reflexes involving eye movement and Purkinje cell recordings from alert transgenic mice.
<![if !supportLists]>· <![endif]>2000-Present: Assistant professor at the Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour. NL. Neurophysiology and neuroimaging in primates. Long-term research aims are to explore how the brain transforms sensory information into perceptual representations and motor acts, and how different perceptual representations interact with different motor pathways.